Breakthrough Prize Recognizes Discovery at MBLof New Organizing Principle in Cells

Clifford Brangwynne, left, and Anthony Hyman were teaching in the 2008 MBLPhysiology course when they first observed condensates forming in cells. Credits: Dee Sullivan, Breakthrough Prize

By Diana Kenney September 22, 2022

WOODS HOLE, Mass. – The discovery of a fundamental way for cells to organize internally, at the Marine Biological Laboratory (��Ůֱ��), has been honored by the awarded to and , then instructors in the course.

The Breakthrough Prize, renowned as the “Oscars of Science,” are presented annually in the fields of life sciences, fundamental physics, and mathematics “to recognize the world’s top scientists working in the fundamental sciences – the disciplines that ask the biggest questions and find the deepest explanations.” Laureates receive a $3 million prize and are honored at a globally broadcast awards ceremony (date to be announced).

Brangwynne, Hyman, MBLPhysiology course students, and colleagues solved a longstanding mystery of how cells create order in the millions of molecules that zip around within their boundaries. As they observed in nematode worms in the course, and later confirmed as a general principle, cells spontaneously form liquid-like droplets that concentrate some molecules in a membrane-free drop, while excluding others. These “condensates,” which usually contain protein and RNA, form by a phase separation process, similar to water vapor condensing into dew.

This observation ended up having major reverberations. Since 2008, evidence has mounted that , from cell division to gene expression, and are involved in the development of diseases that include , , , and others. Several biotech companies have formed to pursue medical applications of condensate research.

“The MBLis the birthplace of this field, because so much happened here,” Brangwynne says, including foundational discoveries that issued from a collaborative, five-year initiative at the MBL(2013-2017) funded by the Howard Hughes Medical Institute.

“The discovery of biomolecular condensates has fundamentally changed how we think about cellular processes and disease,” said MBLDirector Nipam Patel. “It is a tribute to the tremendous value of the ��Ůֱ��’s education and training programs that the original observation was in the Physiology course, and that in the decade to follow, many scientists associated with the MBLvastly extended the observation and pioneered a new field of study.”

The was founded in 2013 by high-tech pioneers Sergey Brin, Priscilla Chan and Mark Zuckerberg, , and Anne Wojcicki.

“The laureates honored today embody the remarkable power of fundamental science,” said Yuri Milner, “both to reveal deep truths about the Universe, and to improve human lives.”

“The 2023 laureates have produced absolutely stellar science,” said Anne Wojcicki. “The creativity, ingenuity and sheer perseverance that went into this work is awe-inspiring.”

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The Marine Biological Laboratory (��Ůֱ��) is dedicated to scientific discovery – exploring fundamental biology, understanding marine biodiversity and the environment, and informing the human condition through research and education. Founded in Woods Hole, Massachusetts in 1888, the MBLis a private, nonprofit institution and an affiliate of the .

Additional resources:

Reflecting on a Super-Productive Summer with the Chromatin Consortium (2023)

Current Condensate Research and Training at the MBL(Summer of 2022)

Description of the Original Discovery in the Physiology Course

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Breakthrough Prize Recognizes Discovery at MBLof New Organizing Principle in Cells

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